II: Reactivity, Kinetics, and Mechanisms 7. Introduction to Structure and Models of Bonding 3 Strain and Stability 65 Solutions and Non-Covalent Binding Forces 145 Molecular Recognition and Supramolecular Chemistry 207 Acid–Base Chemistry 259 Stereochemistry 297 I: Molecular Structure and Thermodynamics Printed in the United Statesof America 09 08 07 06 05 10 9 8 7 6 5 Includes bibliographical references and index. Library of Congress Cataloging-in-Publication Data Ansyln, Eric V., 1960– Modern physical organic chemistry/ EricV. Requests for permission or further information should be addressed to the Permissions Department, University Science Books.
Copyright ᭧ 2005 by University Science Books Reproduction or translation of any part of this work beyond that permitted by Section 107 or 108 of the1976 United StatesCopyright Act without the permission of thecopyrightowner is unlawful. University Science Books Production Manager: Christine Taylor Manuscript Editor: John Murdzek Design: Robert Ishi Illustrator: Lineworks Compositor: Wilsted & Taylor Publishing Services Printer & Binder: Edwards Brothers, Inc. University Scienc University Sciencee Books Sausalito, Sausal ito, Calif California ornia Do Dough ugher erty ty California Institute of Technology Ans Ansly lyn n University of Texas, Austinĭenni De nniss A.
Vinylcyclobutane-cyclohexene reaction in natural p.Modern Mod ern Phy Physic sical al Or Organ ganic ic Ch Chemi emistr stry yĮric Er ic V.Unfortunately, almost all Americans are unaware of it, and I am the Organator sent back from the future to introduce it to them. Happily, it is still available in its sixth edition on Amazon. A true vintage classic, and for its explanations of mechanisms, the best I have ever seen. I had digested it, and Sykes is the epitome of the British pedagogic tradition of explaining concisely and most accurately in one or two statements, something which other textbooks will take two paragraphs to say. Incidentally, the book (and especially the section of E+ aromatic subtitution) reminded me of a jolly good ol thin British book by Peter Sykes- A Guidebook to Mechanism in Organic Chemistry.
Fantastic reference.ĭougherty of course is a great chemist doing some very interesting research ('Physical Organic Chem on the brain' as he calls it) and he gives a swashbuckling talk ('Nicotine is the most common molecule for all SAR studies!') as evidenced by his spiel in the Atlanta Spring 2006 ACS. The book is worth its price, and covers the gamut of topics, including basic ones like mechanism, but also interspersed with lots of boxes explaining the applications of basic phys org concepts to host guest systems, proteins and nucleic acids, strained molecules, and materials science. Now, one can look to a wholesome treatment of phys org as a multidisciplinary, fundamental, and exciting approach to both chemistry and biology. My wait is over Modern Physical Organic Chemistry by Dennis Dougherty and Eric Anslyn has completely and satisfactorily reinvented the phys org chem textbook. Unfortunately, all the classic phys org books until now have been of the 'pure' kind, focusing on mechanism and reactivity, but not discussing the interdisciplinary nature of the topic, especially for biological systems. can be a good computational chemist, synthetic organic chemist, and/or bioorganic/biochemist. I reached the conclusion that phys org is a truly interdisciplinary framework, and any one who has a solid background in phys. As I graduated from school and college into university for my master's, I began to realise that it represents not so much a separate topic as a philosophy and approach to treat chemical and biological systems from the perspective of structure, conformation, and reactivity, which are after all the most fundamental aspects of any such system. has always been one of my favourite subjects.